Open neural tube anomalies are a common fetal structural anomaly that includes anencephaly, spina bifida, and cerebrospinal bulge. Screening for open neural tube abnormalities during pregnancy is done primarily through Down’s syndrome screening. If the result is high risk, open neural tube abnormality is highly suspected and the diagnosis is confirmed by systemic ultrasound, which is usually done twice between 20 and 30 weeks. If the presence of open neural tube abnormality is finally determined, this abnormality is often serious and even if the fetus is retained, treatment after birth is more troublesome, so the vast majority will choose to induce labor. In the case of open neural tube malformation, the main cause is folic acid deficiency, and it is necessary to increase the dose of folic acid during the second pregnancy to reduce the possibility of recurrence of open neural tube malformation.