High aspartate aminotransferase may be caused by physiological factors such as prolonged staying up late, overwork, etc., but it may also be caused by pathologic factors such as liver disease and acute myocardial infarction. 1. Physiological factors: when there are physiological factors such as staying up late for a long time, overexertion, excessive exercise, liking to eat greasy food, etc., it may lead to the phenomenon of high aspartate aminotransferase. 2. Pathological factors (1) Liver diseases: when suffering from viral hepatitis, cirrhosis, liver cancer and other liver diseases, it will cause damage to liver cells and cause high aspartate aminotransferase. (2) Acute myocardial infarction: after suffering from acute myocardial infarction, cardiac muscle cells will die, and aspartate aminotransferase is distributed in a large number of cardiac muscle cells, when the cardiac muscle cells are damaged, the aspartate aminotransferase will also appear to be elevated. In addition to the above reasons, taking certain drugs, myotonic dystrophy, abnormal hormone secretion after pregnancy may also cause high aspartate aminotransferase. It is recommended to consult a doctor in time and complete the relevant tests under the guidance of the doctor to clarify the specific causes of the disease.