Menopausal depression can be self-cured, through psychological counseling methods, so that women in the menopausal transition period can understand the physiological process of the menopausal transition period, and can actively adapt to a more optimistic state of mind. If necessary, an appropriate amount of sedatives can also be used during this serious period to better facilitate sleep, such as taking eszopiclone and ghrelin before going to bed, which can regulate autonomic function and encourage the establishment of a healthier lifestyle, all of which can be beneficial. In addition, perimenopausal women should also adhere to physical exercise, need to ensure a healthy, balanced diet, increase sun exposure time, the need to consume adequate amounts of protein, as well as calcium-rich foods to prevent osteoporosis. Selective 5-hydroxytryptamine reuptake inhibition with paroxetine hydrochloride, if necessary, will be very effective in improving vasoconstrictive symptoms, as well as psychoneurological symptoms. In the vast majority of patients, mood changes and depression are cured spontaneously about 2-3 years after menopause.