What causes cholangiocellular carcinoma? The cause of this disease is not very clear so far, but it is often clearly related to the following factors: i. Congenital choledochal cyst. Chronic cholangitis. Primary sclerosing cholangitis. Intrahepatic bile duct stones. V. Cirrhosis of various causes. VI.Chronic viral hepatitis, such as chronic hepatitis B and chronic hepatitis C. Genetic factors. Certain parasitic infections. Nine, certain carcinogens, such as thorium oxide or nitrosamines and so on. Under the action of these factors, it leads to bile duct epithelial cancer. People who are prone to intrahepatic cholangiocarcinoma need regular annual medical checkups to find out the tumor early and carry out early diagnosis and early treatment.