In diabetic patients, because of the destruction or failure of pancreatic β-cells, the synthesis and secretion of insulin are reduced, and a large amount of glucose cannot be fully utilized by the body and is lost in the urine. In order to maintain the energy needed for life, the body has to break down body fat and protein to produce energy to meet the needs of the body’s tissues and organs, leaving the body in a state of negative nitrogen balance. In addition, the increase of blood glucose will cause polyuria and excretion of large amount of water and various nutrients, resulting in gradual weight loss and wasting. As the disease progresses, in addition to the gradual consumption of subcutaneous fat and skeletal muscle, there are also different degrees of atrophy of organs such as the stomach and intestines, atrophy of the exocrine pancreatic glands, and a significant decrease in the secretion of lipase, trypsin and amylase, which can lead to malabsorption, especially fat malabsorption, and lack of nutrition, further causing wasting. The pituitary, thyroid, adrenal, gonads and other endocrine glands also have varying degrees of atrophy and hypofunction. Reminder: Any reduction of more than 20% from the standard weight is called wasting. In the process of diabetes treatment, this wasting can be improved after scientific treatment and diet control.