Low glomerular filtration rate can lead to elevated blood uric acid concentrations; elevated blood uric acid concentrations are not necessarily due to low glomerular filtration rate.
Uric acid comes mainly from the catabolism of purines in the body and in food. It is mainly excreted by the kidneys. Uric acid concentration is affected by glomerular filtration and tubular reabsorption.
When glomerular filtration is impaired, the filtration of uric acid is reduced, resulting in increased blood uric acid levels; however, elevated uric acid concentrations are not only seen in glomerular filtration impairment, but also in abnormally increased production of uric acid in the body, such as hereditary enzyme deficiencies resulting in primary gout.
High uric acid is commonly associated with excessive uric acid production or decreased uric acid excretion. Low glomerular filtration rate is one of the causes of decreased uric acid excretion.
Patients with low glomerular filtration rate and high uric acid should go to the hospital in time and be treated under the guidance of specialized physicians.