Hepatitis B markers 1, 4 and 5 are positive, and tests such as hepatitis B DNA load need to be monitored for the doctor to assess whether pregnancy is possible. Hepatitis B markers 1,4,5 are positive for Hepatitis B surface antigen, Hepatitis B e-antibody and Hepatitis B core antibody, which generally means that Hepatitis B virus is in the suppression stage and the infectiousness is weakened, but it is necessary to combine with the Hepatitis B virus DNA load in the blood and the liver function to assess the viral replication situation. If the liver function is normal and hepatitis B virus DNA is negative, then pregnancy can be planned. If the liver function is abnormal or the hepatitis B virus DNA load is high, then it is not suitable for pregnancy, which not only increases the chance of the fetus to be infected with hepatitis B but also may lead to the deterioration of hepatitis B disease of the pregnant woman. It is not suitable to get pregnant during antiviral treatment, and it is recommended to get pregnant after 6 months after the end of treatment. Patients with normal liver function should pay attention to monitoring the changes of liver function after pregnancy. If the liver function is normal in the first 24-28 weeks, no antiviral treatment is needed; if the viral load is greater than 6 times 10 in the 24-28 weeks, then tenofovir antiviral treatment is needed in the last trimester of pregnancy. Infants are given a combined blockade of hepatitis B vaccine and high-potency globulin within 12 hours of birth. Whether a positive hepatitis B marker 1, 4 or 5 is suitable for pregnancy should be decided in consultation with a doctor and a comprehensive assessment of liver function and hepatitis B viral DNA load to avoid adverse consequences.