The most effective way to get rid of spots does not exist, and it is necessary to choose suitable treatment methods according to different types of spots. 1. Melasma: symmetrical yellow-brown pigmentation spot on the face, through the external use of hydroquinone cream, tretinoin and other depigmenting agents, it can inhibit tyrosinase activity; Vitamin A acid can affect melanin metabolism, etc., all of which can reduce the production of pigmentation; through the oral intake of vitamin C, vitamin E and so on, it also has a certain curative effect. Laser can also be applied for treatment. 2. Freckles: chemical stripping can be carried out through local application of trichloroacetic acid, phenol and other drugs, and Q-switched ruby laser with a wavelength of 694nm, emerald green gemstone laser with a wavelength of 755nm or IPL can also be applied. There is no most effective way to get rid of spots. When there are spots on the skin area, it is necessary to apply medication under the guidance of doctors and pay attention to sun protection in daily life.