High total cholesterol and LDL may be caused by physiological factors such as long-term high-fat diet and obesity, or by diseases such as nephrotic syndrome and hypercholesterolemia. Patients can follow the doctor’s instructions to choose the appropriate treatment according to the different causes, such as drug treatment, general measures, etc. 1. Physiological factors: It is recommended that patients maintain a light, nutritionally balanced diet, and eat less animal liver, fried food, fatty meat and other high-fat foods recently. If you are obese, you need to lose weight by adjusting diet and exercise to promote fat burning metabolism. 2. Nephrotic syndrome: patients may appear limb edema, proteinuria and other symptoms, you can follow the doctor’s instructions oral aminopterin, spironolactone and other potassium retention diuretic drugs treatment. 3. Hypercholesterolemia: patients may have symptoms such as xanthoma and corneal bowing, which can be treated with oral cholesterol-lowering drugs such as atorvastatin and resuvastatin. It is recommended that patients with high total cholesterol and LDL should go to the hospital as soon as possible for relevant examinations and choose the appropriate treatment according to the cause.