When it comes to gastroscopy, we are not unfamiliar, many people may have unpleasant memories, gastroscopy nausea and vomiting, tumbling and other discomfort so that many people are afraid of gastroscopy from now on, and some people’s first reaction after the examination is even this life never want to do gastroscopy again! Gastroscopy is an important device for the diagnosis and intervention of upper gastrointestinal diseases. With the progress of endoscopic instruments and the improvement of doctors’ operation level, it provides a brand new means for the diagnosis and treatment of digestive diseases, especially the gold standard for the diagnosis of peptic ulcer, esophagogastric fundic varices, bleeding, gastrointestinal tumors, acute and chronic gastritis and other diseases. However, we found that some patients with gastroscopy indications in the clinic, but because of the fear of gastroscopy, try to delay the examination time, resulting in delayed disease, small diseases become big diseases, light diseases become serious diseases, often let people sigh! In order to reduce patients’ discomfort during gastroscopy and meet clinical needs, the hospital has introduced the world’s most advanced Japanese Olympus electronic transnasal fine diameter gastroscope. According to Dr. Zeng Yaoming, Deputy Director of Gastroenterology, our transnasal gastroscope is OLYMPUS GIF TYPE XP150N, with a slim outer diameter of 5.5mm for both the apex and insertion, which is only half of the normal gastroscope, making transnasal and transoral insertion simple and easy, greatly relieving patients’ discomfort, and ensuring ideal observation with excellent image quality despite the thin inner diameter, enabling normal biopsy and hemostasis. Treatment. The preparation for the examination is the same as that of a normal gastroscopy, with fasting for at least 8 hours before the examination and the routine administration of oral anesthetics, except that the nasal cavity must be routinely cleaned and anesthetized before the transnasal gastroscopy, and the subsequent examination steps are similar. Since its introduction in Japan in 2002, transnasal gastroscopy has been well received by patients because it reduces discomfort during the examination. During the trial period of more than 1 month, we found that patients generally felt good during the examination, could communicate with the doctor during the examination, and were willing to undergo gastroscopy again, and very few patients experienced nasal pain and other discomfort after the procedure. Transnasal gastroscopy is especially suitable for patients who cannot tolerate normal gastroscopy or anesthesia gastroscopy such as those of advanced age and cardiopulmonary insufficiency, and contraindications to transnasal gastroscopy are nasal stenosis and turbinate enlargement. We also perform painless gastroscopy, endoscopic hemostasis, esophageal stricture dilation, and percutaneous endoscopic gastrostomy.