The swelling and pain in the big toe can be caused by the following diseases: first, gout, mostly secondary to alcohol consumption or induced by eating seafood and high purine foods, the patient will experience significant local pain, also accompanied by fever, the acute phase should be promptly given non-steroidal anti-inflammatory drugs, oral Nimesulide dispersible tablets or the application of Celecoxib. It is also important to pay attention to local treatment, and physical therapy can also relieve the symptoms. Second, some patients are caused by diabetic foot, especially the increase in blood sugar or local soft tissue contusion within a short period of time, are prone to induce the occurrence of local infection, the common symptoms are pain and fever, check the local skin temperature increased or a significant sense of fluctuation. In this case, you should promptly opt for surgery for incision and drainage, along with anti-infection treatment, regular wound dressing changes, monitoring blood sugar changes, and promoting healing.