Parents of children with congenital heart disease often wonder why a child born with congenital heart disease would have congenital heart disease when neither spouse has heart disease. First of all, it is important to clarify that congenital heart disease is not the same as genetic disease. The causes of congenital heart disease are complex, with both genetic factors and environmental effects. A small number of congenital heart diseases are genetically related, mostly to chromosomal abnormalities or genetic mutations, and such patients may often have other systemic diseases, including mental retardation and immune deficiencies, in addition to heart disease. These patients often have other systemic diseases, including mental retardation and immune deficiencies, in addition to heart disease. However, in congenital heart disease without chromosomal abnormalities or genetic mutations, the chance of having the next generation is higher than that of the normal population, but the majority of patients have a normal next generation. Congenital heart disease occurs mainly because the heart development process goes wrong during the fetal period, so any factor that interferes with the development of the heart can cause the disease to occur, whether it is environmental or genetic. So both husband and wife do not have heart disease, the child born will still have congenital heart disease. Common causes of congenital heart disease are: rubella, influenza, coxsackievirus infection; folic acid deficiency in pregnant women; the effects of various physicochemical factors during pregnancy: such as taking antitumor, anticoagulant or antiepileptic drugs, etc.,; pregnant women with diabetes, etc. Exposure to animals with the potential to cause parasitic infections, etc. According to the above common causes, the preventive measures taken are: 1, in early pregnancy (before 3 months) try not to sit too long in front of the computer, microwave ovens and other places with strong magnetic fields, because at this time the fetus is still unstable, various organs are still forming stage, it is likely to cause congenital heart disease in children. 2, do not touch the pets, because the bacteria and microorganisms on the pets may also cause congenital heart disease in children. 3, should pay attention to the mother’s pregnancy, especially in the early pregnancy health care, such as active prevention of rubella, influenza, mumps and other viral infections; avoid exposure to radiation and some harmful substances; under the guidance of doctors to use drugs; pay attention to a reasonable diet to avoid nutritional deficiencies; prevent local mechanical compression around the fetus. 4, advanced maternal age, that is, the age of more than 35 years old pregnant women give birth to babies with a significant increase in the risk of genetic. Advanced maternal age, be sure to do prenatal physical examination and post-pregnancy follow-up. 5, before pregnancy both parents hospital to do a perfect pre-conception examination, before pregnancy to exclude or treat some diseases that may cause congenital heart disease, for the prevention of congenital heart disease is very important. 6, parents quit smoking and drinking before pregnancy, and mothers take oral folic acid, which is helpful to reduce the occurrence of congenital heart disease. There are many causes of congenital heart disease and the specific mechanism is not clear, completely guaranteeing that it does not occur cannot be done at present, however, we can make various efforts that can significantly reduce the possibility of the baby having the disease.