1. Proteinuria is present, with 24h urine protein exceeding 1 gram. 2, hypertension, these patients’ kidney function is easy to deteriorate. 3.Patients whose kidney function is bad at the onset, the blood creatinine is elevated, which also predicts the deterioration of kidney disease. 4, among various kidney diseases, diabetic nephropathy, polycystic kidney, acute nephritis, amyloid nephropathy, and membrane proliferative glomerulonephritis, the prognosis of these are not very good, are prone to kidney function bad turn.