High GGT glutamyltransferase does not require medication if it is a physiologic manifestation; pathologic conditions often require medication. Elevated GGT glutamyl transferase may be physiologic, such as excessive fatigue, oily diet, etc., which often does not require medication. Symptoms can often be relieved after controlling the causative factors, controlling a light diet, avoiding late nights and excessive fatigue, and maintaining adequate rest. Pathogenic factors, such as acute and chronic viral hepatitis, need to take glycyrrhizic acid preparations, tenofovir and other drugs for liver protection, lowering enzymes, antiviral and other drug therapy. Alcoholic and drug-induced liver damage requires abstinence from alcohol, cessation of drugs causing liver damage, and use of hepatoprotective drugs, while primary biliary cirrhosis requires ursodeoxycholic acid and other drugs. Therefore, high GGT does not always need to take medication, but need to be examined first to clarify the cause before adopting the appropriate treatment program. It is recommended to consult a doctor for standardized diagnosis and treatment if necessary, and not to delay the diagnosis and treatment due to negligence.