Pain in the middle depression of the sole of the foot is not necessarily caused by gout. Common causes of pain in the middle depression of the sole of the foot include the following: 1. Gout: It can cause pain in the sole of the foot, and more often than not, it causes pain in the bunion joint of the foot. If gout is suspected to be caused by gout, you need to test the blood uric acid level, if the blood uric acid is higher than normal, there are no other triggers of plantar pain, it may be related to gout, you need to reduce the uric acid, and at the same time, take non-steroidal anti-inflammatory and analgesic drugs can be relieved; 2, plantar fasciitis: also known as metatarsophalangeal fasciitis is a more common factor in plantar depression pain, and the development of the foot morphology, usually wear the shoes related to. If you wear shoes with flat soles and no heel, the metatarsal fascia in the middle part of the foot will suffer from pain because of the excessive bearing force, which will form metatarsal fasciitis over time, and then cause chronic pain. If you wear shoes without heels for a long time, it is recommended to switch shoes and wear shoes with heels of about 2-3cm to be more scientific.