High-risk HPV virus persistent infection for many years, there will be some more obvious early symptoms, but these symptoms are either easy to be ignored by us, or easy to be confused with other diseases, last time we talked about low back pain, in fact, some patients with nocturnal enuresis, acne serious and so on are infected with high-risk HPV virus accompanied by cervical inflammation state have a relationship with the problem of nocturnal enuresis today we talk about the problem of nocturnal enuresis. Case Sharing: This female patient is less than 50 years old, is also a serious nighttime urinary frequency, but not to the state of incontinence, the interval between nighttime urination is not more than half an hour, not only do not dare to drink water before going to bed, in order to reduce the number of nighttime urination, she has been insisting for many years after noon began not to drink water, but the number of nighttime urination has not yet been relieved, the amount of urine each time is not too much, that is, it is always felt that there is a sense of peeing. She went back and forth to the hospital many times and could not find the reason. The long time frequent night risings led to insomnia, disorganized life pattern, emotional anxiety and nervousness, and finally divorced her husband. She came to our clinic because of her high-risk HPV infection, which was detected during the screening for two cancers in her organization, with a value of 2,000,000 and a TCT result of CIN2-3. Because she did not realize that nocturia was related to cervical inflammation, I did not know about her frequent urination until one month after the treatment of cervical inflammation and viral infection, she said to me during a normal clinic visit, “Doctor, you can save me, my nocturia and insomnia have improved by 70% to 80%.” I said, “Don’t worry, when you get further along in your treatment of cervical inflammation and your cervical status gets better and better, all of these problems should be resolved, feel it for yourself and give me feedback.” About 4 months or so later, the cervical HPV test had turned negative, and she gave me feedback that the nighttime urination problem was completely resolved, and that she could go to sleep from about 11:00 p.m. until she was awake at about 6:00 a.m., and that she was finally able to get a solid night’s sleep! About 40% of HPV infected patients have different degrees of nocturia symptoms. So what viral infection is associated with excessive nocturia? Generally speaking, the number of times of nocturia is 0-1, if you get up 2 or more times, you can be judged as nocturia. Causes of nocturia are drinking too much water before going to bed, neurological factors, nephropathic nocturia, bladder muscle relaxation, etc., in addition to the exclusion of the above factors, then we have to consider inflammatory stimuli (including prostatitis, urethritis, pyelonephritis, etc.), if you do the relevant tests to determine that are not the above reasons, nocturia patients, especially female friends, we need to change the angle of the test we want to do the test, we want to do the test mainly for the Cervix, a TCT test, a high-risk HPV virus test. Simple high-risk HPV virus infection will not cause urinary frequency and urgency, but if the virus continues to be infected for many years to cause cervical inflammation, it is easy to frequent urination, nocturia, and this frequent urination and the position has a lot to do with, compared to the normal frequency of urination is different, the frequency of urination here is prone to occur when lying down. We know that the structure of the human body, the bladder is located before the uterus, that is, when lying down, the bladder is pressed on the uterus. If there is inflammation of the cervix or precancerous lesions, in this position of lying down, it will stimulate the bladder in front of it and cause urinary consciousness. And clinical studies have shown that there is a strong correlation between different cervical conditions and the HPV virus. As the severity of cervical lesions increases, the detection rate of high-risk HPV gradually increases. Nocturnal polyuria, together with the previously mentioned lumbosacral pain, are some of the early symptoms in some people with persistent high-risk HPV virus infection. Nocturnal polyuria needs to be considered as an HPV infection if no cause can be found even after a number of tests have been performed.