Multiple gallbladder stones with cholecystitis, also known as stone cholecystitis, can be treated with medication and surgery. 1. Medication: Different medications are used for asymptomatic patients and symptomatic patients. Symptomatic patients use antispasmodic painkillers such as scopolamine to relieve spasms and pain symptoms; anti-infective drugs such as cefoperazone for anti-infective treatment. 2. Surgical treatment: there are prophylactic cholecystectomy, cholecystectomy. (1) Prophylactic cholecystectomy: it is suitable for high-risk people who are susceptible to gallbladder cancer, stone diameter is larger than 2~3 cm, gallbladder stones for more than 10 years, and patients with porcelainized gallbladder. (2) Cholecystectomy: laparoscopic cholecystectomy is mostly used for radical treatment of gallstones, for patients with acute attacks and severe complications. If stone cholecystitis occurs, it is recommended to consult the doctor in time and treat it actively under the doctor’s guidance.