Pancreatic cancer is a malignant tumor of the gastrointestinal tract with insidious onset, rapid development, and very poor treatment and prognosis. It includes cancer of the head of the pancreas and cancer of the tail of the body of the pancreas. 90% of pancreatic cancer is ductal adenocarcinoma. Pancreatic head duodenectomy is the main surgical means to treat this disease. Surgery Surgery is currently the most effective treatment for pancreatic cancer and is also an effective palliative measure to address patient symptoms and improve quality of life. Effective resection of tumor is still the most important independent factor affecting the prognosis of pancreatic cancer patients. Surgery for pancreatic cancer is complex, with many resected tissues, high risk, trauma and complications, but with the advancement of surgical techniques and perioperative management techniques, the safety of pancreatic surgery is gradually improving. For unresectable pancreatic cancer, comprehensive treatments such as chemotherapy, radiotherapy and immunotherapy can be used. Its aggressive chemotherapy helps to relieve symptoms, prolong survival and improve quality of life. Radiation therapy can be divided into external radiation therapy and intraoperative radiation therapy. For unresectable pancreatic cancer, intractable pain can be relieved by external radiation therapy. For those who cannot tolerate radiotherapy, the best supportive treatment such as nutritional support and pain relief can be used. No effective screening or early diagnosis method has been found for pancreatic cancer, and the prognosis is poor, so early diagnosis and treatment should be done.