Hepatitis B triple positive cannot be completely cured, but the prognosis can be improved through timely medical treatment and antiviral therapy. Hepatitis B triple positive refers to a state in which hepatitis B patients are positive for hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antibody, indicating that the virus in the patient’s body is in an active state. Patients in this stage need timely antiviral treatment, can follow the doctor’s instructions to take entecavir, tenofovir and other related drugs to inhibit the replication of the virus in the body, alleviate the clinical symptoms, reduce the liver function damage, prevent further development of the disease, and actively accept the treatment of the patient can generally get a good prognosis. Because the current medical technology can not remove the virus in the body of hepatitis B patients, therefore, hepatitis B triple positive patients can not be completely cured.