Immunohistochemistry is usually recommended only when there is a high level of lesion in the cervix. A normal cervical biopsy is able to detect the problem of lesions in the cervix and immunohistochemistry is not required. However, if heterogeneous cells are found in the pathology of the biopsy, immunohistochemistry may be required for high-grade lesions. Since there is no way to confirm the diagnosis of some diseases, immunohistochemistry is needed for examination and diagnosis. Therefore, immunohistochemistry is mainly performed to detect the nature of lesions more accurately, such as squamous cell carcinoma or glandular cell carcinoma. However, after immunohistochemistry, the heterogeneous cells are not found to be malignant, therefore, in this case, it is not necessary to take pathological specimens for immunohistochemistry, and the diagnosis can be confirmed based on the specimens of cervical biopsy.