Grey nails are a common clinical condition caused by fungal infection of the nail plate and the nail tissue. In clinical practice, antifungal medications are recommended for the treatment of gray nails. Fluconazole is a broad-spectrum antifungal medication that can be used to treat gray nails, and patients can reap the benefits of using fluconazole to treat gray nails in the clinic. Patients need to be aware that fluconazole is used to treat gray nails in an oral formulation, but it is not recommended that patients simply apply oral antifungal medication for the treatment of gray nails. This is because treatment with oral antifungal medication may not be as effective as treating gray nails with topical medication in conjunction with oral antifungal medication.