Fluconazole as an antifungal drug has certain side effects, which can cause liver and kidney function damage, commonly seen in the following cases: 1, liver function damage: that is, drug-related liver damage, patients can experience fullness and discomfort in the right upper abdomen, and even induce necrosis of liver cells and hyperplasia at liver fibers, even leading to liver failure, which can be accompanied by jaundice, skin pruritus, significant decrease in albumin and significant increase in transaminases; 2, renal impairment: In case of renal impairment, the patient can have increased uric acid and creatinine. If the above situation occurs, patients need to stop using fluconazole or take corresponding alternative drugs, and use liver-protecting and kidney-protecting drugs, such as reduced glutathione, compound glycopyrrolate and a series of other drugs, which may restore the patient’s liver and kidney function to the ideal level.