The steps of heat stroke first aid are divided into on-site first aid and in-hospital first aid, on-site first aid: after finding the patient should be immediately removed from the high-temperature environment, transferred to a cool and ventilated place, remove the whole body clothing and apply cool water spray or wet towel to wipe the whole body to achieve the effect of rapid cooling, while monitoring vital signs. After transferring to the hospital, perform physical cooling, such as ice cap, ice blanket or 40 ℃ saline enema, autologous blood cooling and transfusion, etc. It is necessary to monitor the vital signs, urine color and volume. If a comatose patient is encountered, tracheal intubation should be performed to keep the airway open to prevent vomit aspiration. For patients with intracranial hypertension, 20% mannitol should be used to lower cranial pressure rapidly. Patients with low blood pressure should be rehydrated rapidly with saline or Ringer’s solution, and potassium should be replenished with urine. In case of multi-organ failure, hemodialysis or peritoneal dialysis should be performed, and proton pump inhibitors or H2 receptor antagonists should be applied to prevent stress ulcers in the gastrointestinal tract. Plasma and platelets may also be transfused to prevent bleeding if patients with DIC are encountered.