Itchy yellow skin all over the body is considered to be jaundice, which is caused by serum bilirubin exceeding normal values. Jaundice refers to the phenomenon of elevated bilirubin concentration in the serum caused by bilirubin metabolism disorders, resulting in yellowing of the sclera, skin, mucous membranes and other tissues and body fluids. Because the sclera contains more elastic scleroproteins, which have a stronger affinity for bilirubin, scleral yellowing in patients with jaundice is often first detected before mucous membranes and skin. When serum total bilirubin (normal range 17.1-34.2μmol/L) exceeds the normal value and cannot be observed by the naked eye, it is called hidden jaundice; when the bilirubin level exceeds 34.2μmol/L, clinically visible jaundice occurs, which is called overt jaundice. Jaundice can be caused by various etiological factors such as liver function injury, hemolysis, biliary obstruction and other diseases, appearing as lemon, dark yellow, yellow-green and greenish-brown changes in the skin, and may be accompanied by itching of the skin, dark urine, and lightened feces or white clay-colored stools. Itchy yellow skin all over the body is recommended to consult a doctor in order to clarify the diagnosis, under the guidance of the doctor to carry out targeted treatment.