As we all know, some people like to get married, build houses, move, travel often like to “choose the day”. It has long been a matter of course to see a doctor and take medicine. Do you have to “choose the day” to see a doctor and take medicine? Recent medical research has found that the treatment of “timing” can be twice as effective. At first glance, it does sound a bit new, but there is absolutely no superstition in this. Since most of the body’s organs function in a rhythmic manner, such as heart, brain, inhalation, sleep and wakefulness, blood and urine composition, women’s menstruation, and so on. Such temporally predictable cyclical changes in body functions are of great value in the diagnosis and treatment of diseases. Therefore, the traditional focus on what the patient’s complaints are, whether treatment is needed, what drugs or means of treatment are used, and what doses of drugs are used is not sufficient. Now it is also necessary to pay attention to the chronological factors. 1, disease occurrence has a time regularity, according to the high incidence of disease prevention work According to Dr. Rimas of the University of Helsinki, Finland, the study found that the onset and severity of many diseases have a time characteristic, and understanding their laws, help the diagnosis and prevention of disease. For example, allergic rhinitis often worsens in the morning when waking up and decreases during daytime activities. Asthma mostly attacks during sleep at night, and is more than 100 times more likely to occur during the day, especially at 4 a.m. Exertional angina is likely to occur during the first few hours of daytime activity, while variant angina usually occurs during nighttime sleep, especially between 2 and 4 a.m. Acute myocardial infarction is most often seen during the day, especially in the morning, and is three times more likely to occur during the day than at night. Ischemic strokes, or cerebral infarctions, occur mostly in the morning, while hemorrhagic strokes occur most frequently from late afternoon to 22:00 p.m. Convulsive seizures tend to occur at a specific moment and the moment of seizure varies from person to person, but the time of each seizure is almost always the same in the same patient. Vascular migraines occur more often in the morning upon awakening or at the beginning of daytime activities. Rheumatoid arthritis symptoms increase in the early morning when waking up, while symptoms of proliferative osteoarthritis often occur during daytime activities, especially after the afternoon. Ulcer pain mostly occurs within the first few hours after sleep. 2, see the doctor to choose the time of the examination, the diagnosis is more accurate According to the British medical experts Dickinson research shows that the results of many tests are also affected by the time of day, so this factor must be taken into account when interpreting the test results. The incidence of positive skin tests for allergic reactions to antigens, such as penicillin skin tests, can vary by a factor of three within 24 hours, and is generally lowest in the morning and highest in the evening after bedtime. Whistle ventilation tests, which reflect lung function, are often better during the day and worse at night, with a 25% difference in maximum whistle volume and 1-second forceful whistle volume in patients with mild asthma and even a 50% difference in patients with severe asthma. In addition, the normal range of values for some tests is affected by the time of the test or blood collection. For example, the concentration of plasma adrenocorticotropic hormone cortisone is higher in the early morning and lower in the afternoon and evening. In ambulatory blood pressure monitoring, the normal range of the average blood pressure during the day and at night is different. Therefore, to determine whether some test data are abnormal, the criteria for normal values at different time periods need to be used. Therefore, if the results of tests done at different hours are inconsistent, it does not necessarily indicate an error in the test or a change in the condition. For this reason, you should choose the right hour to do the test to reduce the relative error and get the most correct diagnosis. 3, some drugs taken at the right time, the best effect Professor Blackburn of the University of Minnesota research shows that different times to take drugs can significantly affect the absorption and utilization of drugs in the body. Such as the treatment of asthma long-acting aminophylline, the body’s ability to use the drug, taken at 21:00 in the evening is three times more than the morning 6:00 dose. The anti-platelet drug aspirin, taken at 7:00 a.m. than at 19:00 p.m. drug clearance time is prolonged by 4 to 5 hours. Taking the same dose of the antihypertensive drug nifedipine, the maximum plasma concentration can be achieved when taken at 8 a.m. Different times of drug administration can also significantly affect the effect of drugs in the body. For example, the local anesthetic and analgesic effect of lidocaine is greatest at 3 p.m. and can be twice as great as in the morning or evening; the probability of stomach bleeding caused by taking aspirin in the morning is twice that of taking it in the evening; the anticoagulant effect of heparin is greatest in the afternoon and least in the evening. Therefore, the best time to take medication, especially in preventive treatment, should take into account the time when the disease is prone to attack, the absorption and utilization of medication in the body at different times, and the size of drug effects and side effects occurring. For example, asthma patients should take it before going to bed. When treating ulcer disease, H2 receptor antagonists should be taken at night, while the proton pump antagonist Loxacor is taken in the morning. Since lipid synthesis in the body is stronger at night, lipid-lowering drugs should generally be taken just before bedtime. When oral long-acting nitrates are used to prevent the occurrence of angina pectoris, they should be taken in the morning if they are exertional; if they are variant, they should be taken before bedtime instead.