Colonoscopy is a very common clinical examination nowadays, especially for the early detection of colorectal tumors, which is very helpful. However, when it comes to colonoscopy, many people will be afraid of it. Indeed, because of the complex shape of human intestine, the operation of colonoscopy is very demanding, and it is not very comfortable to perform colonoscopy. Patients vary greatly in their tolerance of colonoscopy, and some patients who are sensitive to pain may scream in pain and have difficulty cooperating, even leading to failure of the examination and inability to continue. How to reduce the pain of colonoscopy for patients and ensure the successful completion of the examination. We first introduced the single operator technique, and later carried out painless colonoscopy under anesthesia. However, the patient is unconscious during anesthesia and the patient is very passive, making the risk of complications likely to increase. In addition the additional cost of anesthesia adds to the financial burden of the patient. To solve this problem, we reviewed a lot of information and repeatedly argued to introduce music into the colonoscopy. After nearly two months of comparative observation, we found that by listening to music for colonoscopy, the subjects became more relaxed and their tolerance for pain increased; as the patients would not be overly nervous, the degree of cooperation in the examination was high and the failure rate decreased significantly; originally, some patients had intestinal spasms that affected the examination results because of nervousness, but now, in the background environment of music, the subjects relaxed and their intestines were more relaxed, so the examination was also smoother. Therefore, the examination is also smoother and the examination time is effectively shortened. In addition, by talking to patients about music during the examination, it not only diverted patients’ attention and reduced pain, but also brought the distance between doctors and patients closer and harmonized the doctor-patient relationship, reflecting the “patient-centered” service concept.