The timing of rotavirus vaccination depends on the child’s physical condition, the epidemic season of the virus and other factors, and needs to be analyzed on a case-by-case basis. Rotavirus infectious enteritis is an infectious disease that endangers the health of children, with a high incidence in late autumn and early winter. The rotavirus vaccine is generally used for children from two months to three years of age, but the timing of rotavirus infectious diarrhea varies from region to region because of the characteristics of climate change. The peak period of infection in northern regions is usually from September to January each year, and the epidemic season of the virus in southern regions is from November to February. Therefore, it is best to choose June to August for northern children who are vaccinated against rotavirus, and August to October for children in the south. Parents are advised to consult with their pediatrician in advance and get rotavirus vaccination at the right time under the guidance of the doctor for better prevention of rotavirus-infected diarrhea.