Patients with toothache blood pressure will be high, belonging to the stress response. Acute endodontitis attack, pulp tissue congestion, swelling, and produce a large number of inflammatory secretions, resulting in a rapid rise in pressure in the pulp cavity, resulting in severe pain, the whole body is in a state of stress, the patient’s emotions are more tense, triggered by the nerve reflexes, the cardiovascular pressure, resulting in blood pressure over the normal range. When the toothache continues to attack, it can affect the patient’s sleep, rest, and can not chew, eat normally, so that the body’s endocrine system is disrupted, hormone levels are unstable, there is a rapid rise in blood pressure, producing dizziness, nausea and other uncomfortable symptoms. It is necessary to open the pulp and drain or extract the diseased tooth, after the pain is relieved, the patient’s mood is stabilized and the blood pressure can gradually return to normal.