Chromosomal abnormalities can lead to fetal malformations, so it is important to do a good job of preconception checkups during pregnancy so that fetal chromosomal abnormalities can be detected in a timely manner. There are many types of chromosomal abnormalities, the most common being trisomy 21, in which newborns exhibit mental retardation, growth retardation, special facial features, aponeurotic lines on the palms of the hands, accompanied by congenital heart disease, gastrointestinal malformations and other symptoms. For different types of chromosomal abnormalities, the prognosis will be different, but most of them have a poor prognosis, and once chromosomal abnormalities are detected, it is difficult to treat them, and the efficacy of the treatment is not very satisfactory. The prevention of chromosomal abnormalities is better than the treatment, therefore, pregnant women in the early stages of pregnancy should do a good job of timely pregnancy checkups, once found chromosomal abnormalities should be timely under the guidance of the doctor, to take the correct intervention, if necessary, to terminate the pregnancy.