At this time, amenorrhea refers to menopause, and the normal age of menopause for women is around 44 to 54 years old. A woman’s life is divided into 7 physiological stages according to her age and physiological characteristics, such as puberty, childbearing, perimenopause, and menopause; the precursor of amenorrhea can start after the age of 40, last 1~2 years, or even last 10~20 years. The average age of menopause for Chinese women is around 49 years old, and it is related to various factors such as physical condition, genetics, nutritional status, psychology, etc. Physiological amenorrhea before the age of 40 years old is considered as premature ovarian failure, and intervention is needed. Perimenopause and menopause can cause a series of symptoms, such as vaginal dryness, osteoporosis, and easy fracture, due to the decrease of estrogen level. When it seriously affects the daily life, appropriate medication (e.g., estradiol valerate, nilestrol, etc.) can be given to alleviate the symptoms of vaginal dryness and osteoporosis, and to prevent the emergence of chronic diseases of aging. Women with abnormal menopausal age should consult a doctor in time to find out the cause and give appropriate treatment under the doctor’s guidance, and should not blindly use medication on their own.