The pain of pressing on the middle of the sternum may be caused by costochondritis, sternal fracture, gastroesophageal reflux disease, leukemia, etc. The treatment includes medication, general treatment, restoration and fixation, etc., and the use of medication should be in accordance with the doctor’s instructions. 1. Costal chondritis: in the acute stage, non-steroidal anti-inflammatory drugs such as ibuprofen should be taken to relieve the pain. If the symptomatic treatment is not effective, local closed treatment such as local injection of lidocaine can be chosen. 2. Sternum fracture: for sternum fracture without displacement, the main thing is to rest in bed and take non-steroidal anti-inflammatory drugs, such as ibuprofen, when in pain. If displacement occurs, surgical repositioning and immobilization are required. 3. Gastroesophageal reflux disease (GERD): acid-suppressing drugs and gastric mucosa-protecting drugs, such as omeprazole and aluminum thioglycollate, etc., are usually needed. 4. Leukemia: due to malignant lesions in the red bone marrow in the sternum, there is abnormal overproliferation, and periosteal irritation causes pain on pressure. Feasible molecular targeted therapy, such as imatinib. Treatment with chemotherapeutic drugs, such as vincristine. Hematopoietic stem cell transplantation is feasible when available. Pressing pain in the middle of the sternum may also be caused by other causes, and it is recommended that the patient consult a doctor in time to avoid delaying the condition.