Two causes of calf soreness include physiologic soreness, vascular disease, neurological disease, and skeletal muscle pain. 1. Physiological factors: for example, the body standing for a long time, a lot of exercise, overwork and so on lead to the accumulation of lactic acid, can appear the symptoms of calf soreness, usually can be relieved after sufficient rest. 2. Vascular diseases: for example, arterial embolism, atherosclerosis, deep vein thrombosis of the lower limbs, etc., which can lead to arterial stenosis, occlusion, and obstruction of blood circulation in the lower limbs and lead to calf pain. 3. Neurological diseases: for example, herniated lumbar intervertebral disc, spinal stenosis and so on, which lead to nerve root compression and calf pain. 4. Skeletal muscle pain: for example, it is common that gastrocnemius muscle injury, osteoarthritis of the knee joint, flat foot, ankle arthritis, etc. cause skeletal muscle pain, which leads to calf soreness. It is recommended that when the body has calf pain, timely consultation, identify the causes, under the guidance of the doctor standardized treatment.