The most common reasons for sleeping calf soreness are over-exercise, muscle spasm, varicose veins of the lower limbs and so on. 1. Excessive exercise: if the patient exercises strenuously during the day, lactic acid is easy to accumulate in the calf, and the metabolism of lactic acid at night when sleeping may induce calf soreness, which is usually relieved by proper rest. 2. Muscle spasm: If the temperature around the patient is too low when he/she sleeps, the cold stimulation can easily cause muscle contraction, which in turn induces the soreness of the calf, so pay attention to the warmth of the calf. 3. Varicose veins of the lower limbs: the main cause of the patient’s venous valve dysfunction as well as blood reflux, early patients do not have obvious symptoms, with the aggravation of varicose veins of the lower limbs, there may be discomfort in the lower limbs, edema, sensory abnormalities and so on. Caused by sleeping calf pain causes more, may also be related to osteoarthritis, rheumatoid arthritis and other reasons, if the symptoms continue to have no relief, it is recommended to promptly go to the hospital to find out the cause of the disease, by the doctor targeted treatment.