Running lowers LDL cholesterol and should be targeted according to the cause of elevated LDL. Because patients will have certain lipid metabolism when running, it is recommended that patients insist on running, which can increase calorie consumption and reduce LDL levels. If patients have high LDL cholesterol due to frequent consumption of high-fat and high-sugar foods in daily life, such as fatty meats, cream cakes and other foods, they can reduce LDL cholesterol by running, and should actively control the intake of calories, advocate a low-fat diet, reasonable diet, and need to take lipid-lowering drugs, such as statins or ezetimibe, if necessary. It should be noted that if patients have high LDL cholesterol because of diseases, such as hypothyroidism, cirrhosis and other diseases, they are pathologic and cannot be lowered by running. It is necessary to actively treat the cause of the disease. Patients with high LDL cholesterol should control their diet, increase running and other exercises, and on the basis of active consultation to clarify the causes of elevated lipids, targeted treatment for the cause.