Diffuse large B-cell lymphoma is the most common type of adult lymphoma. In clinical manifestations, patients often show rapidly enlarging lymph nodes, 10% to 15% of patients have bone marrow invasion, 40% to 50% of patients have extra-lymph node lesions, and patients often have systemic symptoms such as fever, night sweats, and progressive wasting. DLBCL can occur at any age, but is more common in the elderly, with a median age of onset of 60-64 years and slightly more men than women. The typical clinical presentation is a rapidly enlarging painless mass. Diffuse large B-cell lymphoma has a rapidly progressive course, and without aggressive treatment, the median survival is less than one year, so treatment is required immediately after diagnosis. DLBCL is moderately to highly malignant, but with the advent of immunotherapy, great progress has been made in the treatment of DLCBL, and through standardized diagnosis and treatment, the cure rate is high and half of the patients can be completely cured. For DLCBL patients: life is within reach and can be cured!