Whether creatinine 360μmol/L can be lowered mainly depends on the cause of creatinine elevation. If acute kidney injury such as hypovolemia or obstruction causes elevated creatinine, creatinine may decrease after correcting reversible factors; if chronic renal insufficiency such as chronic glomerulonephritis and other diseases cause elevated creatinine, active treatment may delay the progress of the disease, but usually creatinine can not be lowered. Creatinine is the metabolic end product of creatine in muscle tissue. Creatinine does not bind with protein in the blood and can freely pass through the glomerulus, which is the most commonly used indicator to indirectly reflect the glomerular filtration function. When the renal parenchyma is damaged and the glomerular filtration rate decreases, the blood creatinine concentration will rise significantly. Significantly elevated creatinine can be seen in acute kidney injury and chronic renal insufficiency. 1. Acute kidney injury: If acute kidney injury is caused by insufficient perfusion of renal precursor factors such as volume insufficiency, renal artery stenosis, creatinine level can gradually decrease after treatment to restore perfusion. Or acute kidney injury caused by post renal factors such as urethral obstruction, ureteral obstruction, bladder tumor, etc., creatinine level can also decrease gradually after the obstruction is lifted. 2. Chronic renal insufficiency: If the chronic renal insufficiency is caused by the organic damage of glomerulus itself, such as chronic glomerulonephritis, etc., the damage of kidney is usually irreversible, and the progression of the disease may be slowed down after active treatment, but usually it will not make the creatinine drop down. If patients find creatinine increase, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.