There is no corresponding statistical data on 20-year survival rate of liver cancer after surgery. The prognosis of liver cancer is affected by many factors such as tumor stage, physical condition, treatment method, etc. Clinically, a large portion of liver cancers are already in the middle or advanced stage when diagnosed, and most of them have poor prognosis; the survival time after surgical resection seldom reaches 20 years, and there is no exact statistical data in various guideline books yet. Early-stage liver cancer can receive radical surgery or liver transplantation, with a better prognosis and a 5-year survival rate of up to 70%; the recurrence rate of liver cancer is also higher, with a recurrence and metastasis rate of 40%~70% at 5 years after surgery. Survival time of advanced liver cancer is limited, no matter whether surgery is performed or not, most of the cases can hardly exceed two years; however, it cannot be excluded that individual cases with effective treatment, good and positive mentality and strong physical resistance can have longer survival time. Liver cancer should be detected and treated as early as possible in order to have a high survival rate, so regular medical checkups should be done and timely consultation should be made if there is any discomfort.