Alcohol dependence is a mental and physical disorder that occurs after excessive or prolonged heavy drinking and requires comfort and psychological implication treatment by family or friends. If mania or depression is evident and psychotic symptoms appear, it is best to recommend going to a psychiatric hospital and undergoing antipsychotic treatment. If simple alcohol withdrawal symptoms occur, patients can be given adequate rehydration in the hospital, and at the same time, adequate vitamin supplementation, especially B vitamins, can alleviate their somatic symptoms. In conclusion, alcohol dependence requires comprehensive treatment, which requires the joint attention of society, hospitals and psychiatrists to treat together.