There are three main clinical manifestations of alcohol dependence. The first major clinical manifestation is increased tolerance, which refers to the fact that the drinker drinks more and more frequently, drinks more and more alcohol, and drinks more and more alcohol, so that the symptoms of increased tolerance will develop. The second point is withdrawal symptoms, which refers to the appearance of some uncomfortable clinical symptoms after alcohol-dependent patients stop drinking, such as hand trembling, panic, sweating, insomnia, fidgeting, and even seizures, resulting in serious withdrawal symptoms such as withdrawal delirium. The third point is whether there is a loss of control over drinking behavior, which we call impulsive alcohol seeking behavior. Some patients know that drinking has caused alcoholic cirrhosis, alcoholic gastritis, and even brain atrophy and psychiatric symptoms, but they still can’t control drinking and seeking alcohol, which is the core symptom of alcohol dependence, called impulsive alcohol seeking behavior. Therefore, to sum up, alcohol dependence syndrome mainly refers to the three major clinical manifestations of increased tolerance, withdrawal symptoms and impulsive alcohol-seeking behavior.