The main symptom of brownish-yellow disease arthritis is that the whole body skin, sclera and cornea pigmentation is brownish-yellow, the ear, nose and cartilage can become blue, the edge of the tympanic membrane is grayish-black, and the hearing is often reduced. Due to the lack of uronic acid oxidase, the intermediate metabolites of phenylalanine and tyrosine (uronic acid) cannot be further oxidized and decomposed, and accumulate in the body. This causes the skin, sclera and cartilage to become darker, while uronic acid causes hyperpigmentation of cartilage and other connective tissues, and degenerative arthritis of the spine and peripheral large joints. On the other hand, urinary black acid is excreted in urine, where it is alkalized and oxidized to make the urine darker, so it is also called black aciduria. This disease is a rare genetic disease and rare. How to effectively prevent the ear, nose and cartilage from turning blue? This disease is mainly caused by the hereditary disease brown yellowness, so there are no effective preventive measures. In order to prevent the lesions from involving joints and other organs, patients diagnosed with melanosis should be actively controlled. The prevalence rate is reported to be 3-5 cases per million population abroad. Uric acid tends to deposit in cartilage and degenerate joints. As a hereditary disease, there is no effective drug to prevent this disease, so early detection is the key to prevention and treatment. Attention should be paid to avoid marriage between close relatives, premarital counseling, fertility counseling and regular pregnancy tests to reduce the incidence of the disease. Degenerative changes are the same as in proliferative arthritis. Patients should perform appropriate activities, but should not add weight to the joints. If the patient has severe joint pain and motor dysfunction, arthroplasty may be an option. Dietary control of phenylalanine and tyrosine intake (e.g., natural proteins, potatoes, sweet potatoes) can reduce urinary uronic acid levels. High doses of vitamin C can inhibit the binding of uronic acid pigments to connective tissue, counteract its inhibitory effect on chondrocyte growth and prevent morphological deformation. There is no effective treatment for this disease, and it is unrealistic to restrict dietary phenylalanine and tyrosine intake to reduce urothelial aciduria. Long-term administration of vitamin C may inhibit the oxidation and polymerization of uronic acid and may have some significance in relieving clinical joint symptoms. For the treatment of joint lesions, appropriate rest and physical therapy are the mainstays, and pain medication is given when necessary. In cases where joint deformity has occurred, surgical orthopedics may be indicated as appropriate.