The main symptom of brown yellows arthritis is that the skin, sclera and cornea of the whole body are pigmented with brownish yellow color, the ear, nose and cartilage can turn blue, the edge of the tympanic membrane is grayish black, and the hearing is often reduced. Brownish yellow disease is due to the lack of uronic acid oxidase, so that phenylalanine, tyrosine intermediate metabolites (uronic acid) can not be further oxidation decomposition, accumulation in the body. The skin, sclera, and cartilage become darker, while urea causes hyperpigmentation of cartilage and other connective tissues and degenerative arthritis of the spine and peripheral large joints. On the other hand, urinary black acid is excreted in urine, where it is alkalized and oxidized to make the urine darker, so it is also called black aciduria. This disease is a rare genetic disease and is rare. The prevalence is reported abroad as 3 to 5 cases per million population. Because uric black acid is easily deposited in cartilage, it degenerates joints. The disease is often seen clinically as arthrosis, so it is called brown yellowness arthropathy. What are the preventive methods for turning the ear, nose and cartilage blue? The disease is mainly caused by the hereditary disease fucoidosis, so there are no effective preventive measures. In order to prevent the lesions from involving joints and other organs, patients diagnosed with melasma should be actively controlled. 1. Premarital health examination. Men and women who have established a romantic relationship should have a comprehensive and systematic health checkup before registering for marriage. Particular attention should be paid to avoid inbred marriages. The offspring of consanguineous marriages are several times more likely to have various genetic diseases than those of non-consanguineous marriages. 2, pre-conception genetic counseling. Both men and women or one of them, if there are relatives with genetic diseases, worried about whether they will give birth to children with the same genetic diseases after marriage, they should be consulted whether they can get married. 3, prenatal screening to avoid the birth of affected children. Prenatal screening is mainly for some diseases for which there is no good treatment, and its purpose is to prevent the birth of children with defects. Generally in the 16 weeks-20 weeks of pregnancy, the pregnant woman’s peripheral blood 2-3 ml examination, if found high-risk possibility (high-risk factors more than 1/270), then further amniotic fluid culture, to confirm the diagnosis. 4, should not eat too much containing more phenylalanine and tyrosine food, such as natural protein potatoes sweet potatoes, etc.. These foods can make uric acid levels in the urine to reduce; high doses of vitamin C can inhibit the combination of uric acid pigment and connective tissue, to counter its inhibitory effect on the growth of chondrocytes and prevent morphological deformation degenerative changes. 5, some foods rich in vitaminc should be used with caution, such as cherries, guava, persimmons, oranges, kale cauliflower, vitaminc because it hinders the oxidation of black uric acid and coagulation has the effect of inducing brown yellows disease should be prohibited.