The prevention of viral hepatitis B has three major measures, namely, control of the source of infection, cut off the transmission route and protection of susceptible persons. 1, control the source of infection: serology, clinical and epidemiological information confirmed by the diagnosis of viral hepatitis B patients, the epidemic should be reported immediately, take the appropriate isolation measures, if you need to hospital isolation treatment, the best hospital isolation straight to, for viral hepatitis B patients can be variable isolation date. All patients with viral hepatitis B are transferred away from direct contact with imported food and eating utensils or work with young children. Since most of China is a high prevalence of HBV infection, asymptomatic HBsAg carriers are more, and it is not appropriate to census HBsAg in the population without purpose, so it is more difficult to control HBsAg carriers, which requires those who know they are virus carriers, pay attention to personal hygiene, menstrual hygiene and industry hygiene to prevent their saliva and other secretions from contaminating the surrounding environment and infecting others. HBsAg carriers cannot donate blood or work as cooks or caregivers, but they can engage in other work and study as usual. 2, cut off the transmission of HBV: First, to strengthen the management of blood and blood products, blood donors must do a physical examination before each blood donation, HBsAg-positive people are not allowed to donate blood. Blood stations and biological products units should be in accordance with the Ministry of Health “blood products management conditions” requirements, the production and supply of blood products and biological products containing human components, should be sensitive methods to detect HBsAg, shall not sell and use HBsAg-positive people products. Second, blocking mother-to-child transmission. HBsAg should be listed as a routine prenatal screening item for women, and a special bed should be set up for delivery for HBsAg-positive, especially HBeAg-positive pregnant women, and all instruments in the delivery room should be strictly disinfected. Babies born to HBsAg-positive pregnant women can be blocked with hepatitis B immune protein and/or hepatitis B virus vaccine. Third, to prevent medical transmission, medical and health units at all levels should strengthen disinfection and protection measures, such as syringes for one person, one needle, one tube, various instruments and utensils to implement a person with a disinfection, etc. Fourth, strengthen the service industry’s public tea sets, facial towels, bath towels and haircuts, pedicures and other utensils to adhere to a customer one with a disinfection. 3.Protect susceptible people: Reasonable use of hepatitis B virus vaccine and hepatitis B immunoglobulin. Hepatitis B virus vaccine: mainly used to interrupt mother-to-child transmission and prevention of infants and children, also used for post-exposure prophylaxis of accidental needle stickers. Viral hepatitis B immune globulin: can be used to interrupt mother-to-infant transmission and for post-exposure prophylaxis for accidental needle stickers. It is best given as early as possible, preferably within 24 hours of exposure, and in combination with hepatitis B virus vaccine for booster immunity.