Hepatitis B mothers want to have a healthy baby, suffering from a number of precautions to be delivered, ready to make careful preparations. 1, married women with hepatitis B should plan a serious and comprehensive physical examination before pregnancy, to assess their own physical state, in order to choose the best time to get pregnant: (1) if the woman with hepatitis B for acute hepatitis B, after appropriate treatment and reasonable recuperation, can be cured within a few months, at this time, checking the liver function to return to normal, the hepatitis B viral antigen indicators have been turned negative. The patient can recuperate for a period of time and get pregnant when her strength is fully recovered. (2) Chronic hepatitis B patients should first find out the severity of their condition before deciding whether to get pregnant. If the patient belongs to virus carrier, long-term follow-up examination of liver function series is always normal, ultrasound does not indicate cirrhosis, pregnancy can be considered. If the patient’s hepatitis B inflammation is in the active stage, check liver function abnormalities, self-conscious fatigue, loss of appetite, abdominal distension, etc., this should be avoided to get pregnant, the active stage of liver inflammation hard to get pregnant, the burden on the body increases, the liver has to complete more work, hepatitis is not easy to recover, but instead, it is easy to lead to severe hepatitis, endangering the life of the pregnant woman. In addition, it is not favorable for the development and growth of the fetus. Therefore, patients with active hepatitis B should first receive regular treatment, including antiviral and immunomodulatory therapy. When the liver function returns to normal, the virus replication index turns negative or the replication ability is reduced, then pregnancy, so that both mother and child will be beneficial. If ultrasound examination reveals that the hepatitis has developed to the degree of cirrhosis, accompanied by obvious thrombocytopenia, hypersplenism and coagulation dysfunction, it is better not to get pregnant. Chronic hepatitis B patients with severe extrahepatic systemic manifestations, such as nephropathy, aplastic anemia, etc., it is best not to get pregnant. For patients with active hepatitis who are stabilized after treatment and have normal liver function for more than half a year, it is safer to get pregnant. Those who have a history of pregnancy but terminate the pregnancy because the liver can’t bear it; those who have hepatitis B virus infection with obstetrics and gynecological disorders that are not suitable for pregnancy, such as those who have a history of repeated cesarean section should not get pregnant. Whether or not a hepatitis B virus-infected person can become pregnant is mainly determined by whether or not the liver itself can withstand the burden of the entire pregnancy and delivery process. At present, there are two tendencies that deserve attention and are not desirable. One part of the people want to wait until the infectiousness of hepatitis B virus is reduced to zero or very low level before getting pregnant, which is not realistic, and blindly waiting for it will miss the best time and age for getting pregnant; the other part of the people do not take into account the ability of the body to withstand the burden, and hold the mentality of trying to get pregnant, which is very dangerous. Hepatitis B patients, once pregnant, should terminate the use of a variety of hepatotoxic drugs: such as antibiotics, anti-tuberculosis drugs, treatment of diabetes drugs and so on. If you are at conception and the first 3 months of pregnancy transaminase mildly elevated, no other obvious discomfort, in order to prevent the embryo deformity, it is best not to use drugs, 6 months after pregnancy before you can cautiously use some of the safer enzyme-lowering drugs. The safety of applying antiviral drugs during pregnancy and breastfeeding in women with hepatitis B is not well understood. Common interferon and polyethylene glycol interferon are contraindicated during pregnancy due to their antiproliferative effects. 3, hepatitis B pregnant women during pregnancy, the condition may worsen: manifested as obvious liver function damage, transaminases, bilirubin rapidly increased, patients with nausea, vomiting, fatigue, at this time should terminate the pregnancy, and actively carry out hepatoprotection and antiviral treatment. 4, hepatitis pregnant women’s sexual life should pay special attention to moderation, depending on the situation of hepatitis and the size of the gestational week to adjust: (1) in the fluctuation stage of liver function, serum glutamic aminotransferase instability or jaundice and other conditions, should be prohibited from sexual life. Sexual life should also be suspended during the recovery phase of acute hepatitis and after the relative stabilization of chronic hepatitis and cirrhosis. Hepatitis B virus carriers alone should not indulge in sex either. If you feel tiredness, lumbago, fatigue, weakness, loss of appetite, etc. on the next day of sexual intercourse, you should pay attention to the adjustment and suspend sexual life. (2) Sexual intercourse should be avoided in the first and second trimesters of pregnancy, and should be absolutely prohibited after 36 weeks of pregnancy to prevent miscarriage, premature rupture of membranes and intrauterine infection. (3) Pay attention to the position of sexual intercourse, avoid riding position and flexion position, and prevent the male genitals from penetrating too deeply. Husband should pay attention to the slow movement, do not stimulate his wife’s nipples too much, avoid abdominal pressure, and reduce the activity of pregnant women. (4) If vaginal bleeding, back pain, habitual abortion, hypertensive syndrome of pregnancy occur, sexual life should be absolutely prohibited. (5) Pay attention to sexual hygiene, keep the vulva clean before and after sex, and use penile condom, which can reduce hepatitis B virus infection between husband and wife. (5) Immediate immunoprophylactic intervention after the birth of a newborn by a mother with hepatitis B is the most important measure to prevent hepatitis B from being transmitted from generation to generation: newborns born to mothers who are positive for hepatitis B virus should be injected with hepatitis B immunoglobulin as early as possible, preferably within 24 hours after birth, preferably within 4 hours after birth, with a dose of ≥100 international units, and also be vaccinated with 10 micrograms of recombinant recombinant immunoglobulin at different sites. Vaccination with 10 micrograms of recombinant yeast or 20 micrograms of Chinese hamster oocyte hepatitis B vaccine at different sites significantly improves the efficacy of interruption of mother-to-child transmission. Alternatively, one injection of hepatitis B immunoglobulin can be given within 12 hours after birth, followed by a second injection of hepatitis B immunoglobulin one month later, and at the same time, one injection of 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte hepatitis B vaccine can be given at different sites, and the second and third injections of 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte hepatitis B vaccine can be given at intervals of 1 and 6 months, respectively. oocyte hepatitis B vaccine. The latter is not as convenient as the former, but its protection rate is higher than that of the former. Newborns can receive breastfeeding from hepatitis B virus-positive mothers after receiving hepatitis B immune globulin and hepatitis B vaccine within 12 hours of birth.