You should not drink alcohol when taking Anacin, the medicinal ingredients in Anacin, if interacting with alcohol, may produce new substances that can lessen the anti-inflammatory and antipyretic effects of Anacin. Drinking alcohol can make the side effects of Anacin more pronounced, the most common is the gastrointestinal reaction, alcohol and Anacin is likely to produce side effects on the gastrointestinal tract, which will aggravate the gastrointestinal side effects such as bloating, abdominal pain, nausea, vomiting and even diarrhea. If you are allergic to anandamide, drinking alcohol may aggravate the symptoms of allergy, such as laryngeal edema or even pulmonary edema, respiratory difficulties, and may lead to anaphylactic shock, which is life-threatening.