The role of interferon in the clinic is mainly to improve the body’s resistance and immunity, and does not have a direct role in treating HPV type 16 infection. Clinically, if the high-risk HPV16 infection persists, it will lead to cervical epithelial lesions, such as precancerous lesions, and even develop into cervical cancer. However, in about 80% of patients who are infected with high-risk HPV, the high-risk HPV infection is cleared up in about one year due to the strengthening of their own resistance, and they become clinically negative. In this case, if a high-risk HPV type 16 infection is detected, a colposcopy should be performed first to make sure that there is no epithelial lesion, and a regular review is sufficient. During the review process, if there is any abnormal problem, then timely treatment will be given.