Pruritis ani (peritusani, PA) is a common localized itching condition. There is sometimes a mild itching in the anal area, which becomes pruritus if the itching is severe and persistent. It is a common limited neurologic dysfunction skin disease. It is usually limited to the perianal area, and in some cases may spread to the perineum, vulva or posterior scrotum. It occurs mostly in the midday and old age of 20 to 40 years old, less in young people under 20 years old, and rarely in children. Men are more common than women, and this pruritus occurs more often in people who are used to quiet and infrequent exercise. Secondary pruritus has an obvious causative cause, easy to treat; spontaneous or unexplained PA is not easy to cure, but also often recur, accounting for about 50% of all patients. What are the symptoms of early anal itching? Specific content is as follows: at the beginning of anal itching is light, no obvious changes in the anal skin, mostly paroxysmal. Chronic patients itching is more intense, longer duration, especially at night, excessive scratching or mechanical stimulation of the perianal skin thickening and roughness, deepening of the anal folds, local scratches, scabs, oozing, folds in the seam residual fecal dirt, the worse can be combined with the infection of pus bubbles or purulent secretions, redness and swelling. The lesions may extend to the perineum, scrotum, female vulva and even the skin of both buttocks. Clinical examination may reveal the presence of internal hemorrhoids, external hemorrhoids, mixed hemorrhoids, anal fistula, or diabetes mellitus, pinworms, and Candida albicans infections by laboratory tests.