First, what about the combined cardiovascular and cerebrovascular disease? Cardiovascular and cerebrovascular disease refers to cardiovascular disease and cerebrovascular disease, because of the close relationship between the two, so often combined and mentioned. Anal disease combined with cardiovascular and cerebrovascular disease is not uncommon in the clinic, because the heart is the most important organ of the human body, so the treatment of this type of patients must be careful. Doctors and patients should cooperate, the doctor should ask in detail whether there is a history of cardiovascular and cerebrovascular disease, and the patient should recount the history in as much detail as possible, and should not conceal it. Generally speaking, there are serious cardiovascular and cerebrovascular diseases, such as severe hypertension, cardiac insufficiency, severe arrhythmia, cardiac infarction, etc. should not do anal surgery, but should be conservative treatment. Patients with blood pressure around 150/100mmHg and no obvious clinical symptoms can have anal surgery while taking medication to control blood pressure. Patients with a history of heart disease, but with good effect of medication, insignificant symptoms, and generally normal electrocardiogram, can have anal surgery. Clinical symptoms are mild, the relevant examination is mildly abnormal cardiovascular and cerebrovascular disease, you can do some simple, short operation time, less painful anorectal surgery. Second, what about tuberculosis combined with anorectal disease? Tuberculosis is a chronic systemic wasting disease caused by tuberculosis infection. It is infectious. Tuberculosis patients with weak constitution, gas and blood deficiencies, if you do surgery, the wound is extremely difficult to heal, or even not heal, therefore, combined with tuberculosis of anorectal disease patients in principle should be avoided surgical treatment. For patients who must undergo surgery, anti-TB treatment should be carried out at the same time, and anti-tuberculosis drugs can also be used for local dressing change. Diet should be nutritious, such as cow’s milk, soybean products, fruits, avoid spicy food. Third, diabetic patients with anorectal disease how to do? As we all know, diabetes is a chronic disease. Due to the body sugar metabolism, protein metabolism, fat metabolism and water-electrolyte balance imbalance caused by nutritional disorders, multi-system damage, decreased resistance, and due to elevated blood glucose, affecting the function of the white blood cells, so it is very susceptible to bacterial infection. Diabetic patients who have had anorectal surgery, first, the wound healing is slow, and second, the wound is easy to be infected. So, what do diabetic patients do when they have anorectal disease? First of all, do not panic and fear, but should go to the regular hospital anorectal department to consult. Secondly, it is best to first conservative treatment, while taking medication to control blood sugar. After the blood sugar is normal, surgical treatment can be carried out, as long as the surgery is strictly sterilized, postoperative timely change of medication, with the use of antibiotics, if necessary, insulin gauze change (4 units of insulin per day), the results are very good.