When visiting the clinic, I often hear patients complain that their blood sugar is still poorly controlled after taking insulin. The reasons for this are not only that the diet is not well controlled and the insulin injection dose is not accurate, but also that there are problems in the insulin injection process. The selection of insulin injection device and insulin injection technique specification are important aspects of insulin treatment. If you do not pay attention to it, it will largely affect the insulin glucose-lowering effect. 1, insulin injection device has to be careful Currently commonly used insulin injection device including special syringes, the advantage is that the cost is low, but the operation steps are more cumbersome, the injection process is easy to bacterial infection, and is less used. Insulin pen is the most commonly used insulin injection device, which can be used repeatedly for a long time and contains insulin refills, which can be replaced after use. It is easy to carry, simple and flexible in operation, simple in injection process, and accurate in injection dose. In recent years, a new type of pre-filled insulin injection device, the special filling pen, has been gradually applied, which is simpler and easier to learn than the insulin pen and improves patients’ compliance with treatment because the filling process is eliminated. Patients with diabetes should choose the injection device reasonably according to their financial situation and the type of insulin they use. In particular, it should be noted that the special syringe can only be used to take 400u/10ml of insulin injection. 2, insulin injection time has to be careful Insulin can be divided into ultra-short-acting insulin analogs, short-acting insulin, medium- and long-acting insulin, long-acting insulin analogs and premixed insulin (including premixed insulin and premixed insulin analogs) according to the duration of action. The timing of injection varies among insulins. Ultra-short-acting insulin analogues (such as Novalis, Eugenol, etc.) and premixed insulin analogues (Novalis 30, Eugenol 25, etc.) are injected 5-15 minutes before meals, and if you forget to inject before meals, you can inject during or immediately after meals; short-acting insulins (Novalis R, Eugenol R) and premixed insulins (Novalis 30R, Eugenol 70/30) are injected half an hour before meals. Medium- and long-acting insulins and long-acting insulin analogues (Novolin N, Eugenol N, Novaline, Lexapro) are usually injected once a day before bedtime. The injection site of insulin includes the abdomen, front and outer thighs, outer upper arms and buttocks. The absorption rate and absorption rate vary greatly from site to site. When self-injecting insulin, the priority injection site is the abdomen, followed by the buttocks and thighs. When injecting in the abdomen, avoid the area within 125px of the umbilicus (approximately the area where one of the patient’s fists covers the navel), and inject within about a palm’s width on both sides of the navel. Regarding the injection site, the more important principle is rotation, which is done by dividing the injection site into four equal areas (for the thighs or abdomen it can be divided into two equal areas); a different site is injected each week and then rotated clockwise. The injection areas within the same injection site also need to be rotated, and when it is the turn of this injection site again, a different area within this site is selected for injection (at least 25px away from the last injection site) to avoid repeated tissue trauma. If rotation is not carried out, it can cause subcutaneous fat growth and affect the absorption effect of insulin. 4. The use of needles is important The correct insulin injection should be injected into the subcutaneous tissue. Injecting too deep into the muscle layer will accelerate the absorption of insulin, leading to unstable blood glucose control in the body and increasing the pain during injection. If an 8 mm needle is used, the skin should be pinched up when injecting to avoid injecting into the muscle tissue; if a 4 or 5 mm needle is used, the risk of injecting into the muscle layer is minimal and the skin can be injected directly without pinching up. Since there is a special coating on the insulin injection needle, it can play a role of lubrication during the injection process, but the coating will be damaged after one injection. If the needle is used repeatedly, it can cause microtrauma to the tissue, and the incidence of subcutaneous fatty nodules is also significantly higher, the pain of injection is enhanced, and the risk of infection is increased, and even the needle tip remains in the body and other serious consequences. Therefore, reuse of needles is strictly prohibited. 5. Insulin storage is very important for the proper storage of insulin for its therapeutic effect. Since insulin is a protein product, it will degenerate and fail under the condition of high temperature or freezing. Insulin in use can be stored at room temperature and protected from sunlight. Insulin that has not been opened can be stored in the refrigerator under refrigeration, not frozen. When you travel with insulin, you should avoid cold, heat and repeated shocks, and it is better to carry a thermal box with you. When traveling by air, insulin should be packed in the bag that patients carry with them, and should not be checked in with their luggage, because the temperature in the check-in cabin is too low, which will denature the insulin and lose its glucose-lowering effect. Of course, insulin injection has a lot of considerations, such as premixed insulin and medium-acting insulin need to be shaken well before use; after insulin injection, the needle should be left under the skin for more than 10 seconds to avoid leakage, etc., which is limited by space and will not be introduced in detail. In conclusion, patients with diabetes insulin therapy need to standardize the injection under the guidance of specialist doctors and full-time nurses in order to maximize the effect of insulin therapy and make insulin the most powerful weapon to control our blood sugar.