Abdominal discomfort and weight loss are often considered to be related to indigestion, gastritis, cancer and other diseases, and it is recommended to go to the hospital for abdominal ultrasound or gastroscopy in time. 1. Indigestion: Indigestion may lead to abdominal discomfort, and the prolonged exposure to it may prevent nutrients from being absorbed properly, leading to weight loss. 2. Gastritis: Gastritis is an acute and chronic inflammatory reaction of gastric mucosa caused by many different causes, which usually leads to epigastric pain, accompanied by clinical symptoms such as abdominal distension, nausea, vomiting, and weight loss. 3. Cancer: such as gastric cancer, pancreatic cancer, etc. will have the manifestation of abdominal discomfort, distension, hidden pain and so on. As the disease progresses gradually, there may be obvious weight loss and emaciation. At the same time, it may be accompanied by loss of appetite, nausea, diarrhea and other symptoms. When clinical symptoms such as abdominal discomfort and weight loss occur, it is necessary to go to gastroenterology department in time for further examination and treatment under doctor’s guidance according to the cause of the disease.