Liver cancer patients’ frequent pain in liver area at night is a common symptom of liver cancer, which is mostly due to the large liver cancer mass increasing the pressure of liver, and the mass may pull the hepatic peritoneum causing persistent dull pain. Liver cancer patients’ frequent pain in liver area at night is mostly intermittent or persistent dull pain, which is indeterminate, sometimes more intense and sometimes can be relieved by themselves, usually because the liver tumor grows too fast, and the liver peritoneum is pulled or compressed, and some pain relieving drugs can be taken to relieve the patient’s symptom under the guidance of doctor. It is a normal phenomenon for liver cancer patients to have frequent pain in liver area at night, they should consult doctor in time and take active treatment under doctor’s guidance to reduce their pain.